The Dean of the Columbia University School of Public Health discusses the immense challenges that face an aging population and shares her vision of longevity that emphasizes healthspan, happiness, and individual purpose.

A plastic surgeon and medical historian shares stories of daring surgeons who pioneered the field of cardiac surgery, as well as insights on the aesthetic component of his own practice.

One of the world’s leading experts on vaccines shares how he created the rotavirus vaccine, which now saves hundreds of lives each day, and how we can rebuild trust in public health by acknowledging the limits and promises of science.

The 12th President of the World Bank shares how he has sustained a sense of moral purpose throughout a career marked with immense contributions to global health, poverty reduction, education, and sustainable development.

A philosopher discusses how engaging with the beauty in everyday life answers the question: “what makes life worth living?”

The Chief Scientific Officer at Microsoft discusses what artificial intelligence teaches us about natural intelligence and why AI technologies will enable human flourishing.

The Chair of Surgery at Columbia University Medical Center shares stories of harrowing heart surgeries and how he maintains a moral drive that anchors the daily miracles that define his challenging profession.

A two-time cancer survivor and Co-Founder of the Multiple Myeloma Research Foundation shares her remarkably successful efforts to discover new treatments for her own disease.

Co-hosts Henry Bair and Tyler Johnson reflect on some of the most meaningful lessons and insights they have learned over the course of the first 100 episodes of the podcast.

A complexity theorist and Co-Director of Gastrointestinal and Liver Pathology at NYU Grossman School of Medicine explores how the science of “complexity” explains the emergence of life out of tissues, cells, atoms, and beyond.

The Director of the Johns Hopkins International Arts + Mind Lab and Vice President of Hardware Design at Google discusses “neuroaesthetics” and why creative arts are essential to human health and wellbeing.

A 104-year-old physician and co-founder of the Academy of Integrative Health and Medicine shares how finding love and human connection are key to healing and happiness.

An essayist and cultural critic discusses the value of a liberal education in shaping courageous, imaginative, and moral identities and how this enables us to create purposeful lives.

A health economist and host of the popular Freakonomics, MD podcast shares the hidden drivers behind healthcare and how random chance affects our health outcomes.

A neuroscientist discusses the possibilities of slowing down and even reversing age-related neurodegeneration and the philosophical and ethical implications of life-extension.

A leading medical anthropologist and psychiatrist shares how moments of crises and suffering sharpen our moral identities and how acts of care define our human capacity for goodness.

A philosopher and survivor of more than 10 suicide attempts explores the suicidal mind and shares advice on finding hope amid life’s bleakest moments.

A physician and founder of the Foundation for Art & Healing shares how storytelling and creativity can foster connection and help heal our crisis of loneliness.

The first openly gay president of the American Medical Association shares how his experiences facing discrimination have shaped his LGBTQ advocacy and inclusive leadership.

A physician and explorer shares his epic journey cycling across 6 continents, 75 countries, and 53,000 miles, what his travels have taught him about health care at the margins, and stories of everyday kindness that underscore our common humanity.

A cardiologist and Founding Director of the Resynchronization and Advanced Cardiac Therapeutics Program at Massachusetts General Hospital discusses what clinicians need to do to better prepare themselves for the digital future of medicine.

A writer discusses what it’s like to live with progressive vision loss, explores the subjective experiences and culture of blindness, and discusses how he finds a renewed sense of richness in the world.

A Vice Dean at the Johns Hopkins Bloomberg School of Public Health and former Secretary of the Maryland Department of Health shares the highs and lows of a long career in health policy and where he finds fulfillment amid the intricacies of politics.

An addiction medicine specialist discusses why addiction is far more complex and nuanced than we all think, and shares how she helps her patients heal by connecting with their life purpose.

The Director of the Columbia University Center for Clinical Medical Ethics discusses how she cultivates “moral imagination” in medical trainees and how she acknowledges and responds to suffering.

A psychotherapist, practicing Buddhist, and writer shares how he harnesses Buddhist mindfulness and meditation techniques to help patients overcome suffering by reframing their relationships with their personal stories.

A gynecologist and leading health communicator shares how she addresses overlooked issues in women’s health and how she combats medical misinformation, both through her massive online presence as well as through day-to-day patient care.

An emergency physician and bestselling author shares how she rose out of trauma and now seeks to heal traumas both individual and societal in the emergency room.